DHEA Treatment and Therapy Chandler Arizona

DHEA Treatment and Therapy Chandler Arizona
Dehydroepiandrosterone (DHEA) is a multi-functional steroid that has been implicated in a broad range of biological effects in humans and other mammals. Together with its sulfate ester (DHEA-S), it is the most abundant steroid in humans. DHEA is produced by adrenal glands, but also sythesized de novo in the brain. It acts on the androgen receptor both directly and through its metabolites, which include androstenediol and androstendione, which can undergo further conversion to produce the androgen testosterone and the estrogens estrone and estradiol. DHEA is also a potent sigma-1 agonist. It is considered a neurosteroid.

Synonyms for dehydroepiandrosterone are:

3-beta-Hydroxy-5-androsten-17-one, 3.beta.-Hydroxyandrost-5-en-17-one, 3beta-hydroxy-5-androsten-17-one, 3beta-hydroxy-androst-5-en-17-one, 3beta-Hydroxy-D5-androsten-17-one, 3beta-Hydroxyandrost-5-en-17-one, 3beta-Hydroxyandrost-5-ene-17-one, 3-beta-hydroxy-etioallocholan-5-ene-17-one , 5-Androsten-3beta-ol-17-one,


Brand names for DHEA include Prastera, Prasterone, Fidelin and Fluasterone. Supplement versions are manufactured from wild Mexican yam.

Dehydroepiandrosterone sulfate

Dehydroepiandrosterone sulfate (DHEAS) is the sulfated version of DHEA. This conversion is reversibly catalyzed by sulfotransferase (SULT2A1) primarily in the adrenals, the liver, and small intestine. In the blood, most DHEA is found as DHEAS with levels that are about 300 times higher than those of free DHEA. Orally ingested DHEA is converted to its sulfate when passing through intestines and liver. Whereas DHEA levels naturally reach their peak in the early morning hours, DHEAS levels show no diurnal variation. From a practical point of view, measurement of DHEAS is preferable to DHEA, as levels are more stable.


DHEA is produced from cholesterol through two cytochrome P450 enzymes. Cholesterol is converted to pregnenolone by the enzyme P450 scc (side chain cleavage); then another enzyme, CYP17A1, converts pregnenolone to 17α-Hydroxypregnenolone and then to DHEA.


Role

DHEA can be understood as a prohormone for the sex steroids. DHEAS may be viewed as buffer and reservoir. As most DHEA is produced by the zona reticularis of the adrenal, it is argued that there is a role in the immune and stress response.

As almost all DHEA is derived from the blood measurements of DHEAS/DHEA are useful to detect excess adrenal activity as seen in adrenal cancer or hyperplasia, including certain forms of congenital adrenal hyperplasia. Women with polycystic ovary syndrome tend to have elevated levels of DHEAS.

DHEA is a weak androgen produced in the adrenal glands, and it's one of the main precursors of testosterone. You may have heard that DHEA is 2 steps away from testosterone. What this means is just that DHEA first converts into either Androstenedione or Androstenediol, which is then converted into DHEA. 
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With age, DHEA levels can decline up to 90%, and it peaks in your 20's. Because DHEA is a main precursor of testosterone, it's often used to boost sex hormone levels, and used by athletes to boost testosterone levels. Studies have shown that supplementing 50-100mg of DHEA per day helped increase muscle mass and improve overall health condition in 40 to 70 year old subjects.

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